The latest news:
Membrane proteins (MPs) are known to be key molecules
in cellular communications, from signal transduction to transport of ions,
metabolites and other molecules. They also participate in the synthesis of ATP,
the import of soluble or MPs from the cytosol, and they protect living
organisms from toxic factors.
The proposal consists in a joint training effort
involving the major biophysical methods that are -or soon will be- the major
techniques used in the field of structural biology of MPs. A collaborative effort
is essential for the training of the future generation of biologists dedicated
to membrane proteins. It will pave the way to an integrative approach for the
study of structure-function relationships of membranes. It will therefore open
new strategies for structure-based drug design, in particular toward G-protein
coupled receptors (GPCR), which are major drug targets (GPCRs represent 30% of
current drug targets). The training proposed in this program will not only form
high-level academic researchers but will also largely contribute in forming the
main actors of the future developments in biotechnology and personalized
medicine.
This network combines 13 academic research groups and
3 industrial companies interested in collaborating with these groups and
involved in drug discovery or scientific equipment for SBMP. These groups are
internationally recognized for analysing the structure and dynamics of membrane
proteins by a combination of experimental and theoretical approaches: in vivo
and in vitro expressions systems, functional/biochemical/biophysical
characterisation, X-Ray diffraction, electron microscopy (EM), atomic force
microscopy (AFM), single-molecule force spectroscopy (SMFS), liquid and solid
state NMR, numerical simulations. Seven partners from 6 different countries are
involved: France, Poland, Portugal, Switzerland, Germany and the Netherlands.